Effects of chronic maternal stress on hypothalamo-pituitary-adrenal (HPA) function and behavior: No reversal by environmental enrichment

► Chronic maternal stress increases locomotor activity in adult male offspring. ► Chronic maternal stress decreases sensorimotor gating in adult female offspring. ► Environmental enrichment does not reverse behavioural modifications in adult offspring. ► Enrichment modifies HPA function and behaviour independent of chronic maternal stress.