First catalytic synthesis of 7-ferrocenyl-2,4-dioxopyrido [2,3-d]pyrimidines derivatives in water

The reaction of 6-amino-1,3-dimethyluracil with substituted ferrocenyl-ketoalkynes using nickel cyanide as homogeneous catalyst precursor in aqueous alkaline medium, affords 7-ferrocenyl-2,4-dioxopyrido[2,3-d]pyrimidines derivatives, in moderates yields under mild conditions.