کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6802524 | 543073 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Retrospective Evaluation of Inpatient Transfer from High-Dose Methadone to Buprenorphine Substitution Therapy
ترجمه فارسی عنوان
بررسی مجدد انتقال سرپایی از متادون با دوز بالا به بوپرنورفین جایگزین درمان
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کلمات کلیدی
بوپرنورفین / نالوکسون، متادون، منتقل کردن، بستری دوز بالا،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The product license of buprenorphine/naloxone for opioid substitution therapy indicates reducing methadone concentrations to 30Â mg or less per day for a minimum of 1Â week before transferring patients to buprenorphine and no sooner than 24Â hours after the last methadone dose, because of the risk of precipitated withdrawal and a corresponding high risk of relapse to opioid use. There are few studies describing high-dose methadone transfers. This retrospective case review assessed the feasibility of transferring patients on methadone doses above 30Â mg/day to buprenorphine or buprenorphine/naloxone in the inpatient setting. Six of seven patients on 60-120Â mg/day of methadone successfully completed the transfer, and four cases tested negative for opiates at long-term follow-up (6-15 months). This suggests that methadone transfer to buprenorphine can be performed rapidly without the need to taper methadone doses in patients indicated for a therapeutic switch. This small study is hypothesis-generating; larger, well-designed trials are needed to define a protocol that can be used routinely to improve and widen transfers to buprenorphine when indicated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Substance Abuse Treatment - Volume 57, October 2015, Pages 102-105
Journal: Journal of Substance Abuse Treatment - Volume 57, October 2015, Pages 102-105
نویسندگان
Rossana MB, BS, BSc (Hons), MSc, FRCPsych,