Esterification of mandelic acid catalyzed by heteropoly acid

The efficacy of various supported heteropoly acids in synthesis of mandelates from mandelic acid and alcohols is investigated. Dodecatungestophosphoric acid (PW) supported on silica gives the best yield in short reaction times. The present procedure represents a clean, practical, simple, mild, time-saving, and eco-friendly method for synthesis of mandelates in short reaction times and excellent yields with 100% selectivity. The catalyst is found to be stable, highly efficient, reusable, and inexpensive during all runs.

The efficacy of various supported heteropoly acids in synthesis of mandelates from mandelic acid and various alcohols is investigated.The results demonstrate that SiO2 can be regarded as the best support for HPAs in comparison to other supports. The present procedure represents a clean, practical, simple, mild, and time-saving method for synthesis of mandelates with excellent yields and 100% selectivity.Figure optionsDownload as PowerPoint slide