کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6808157 | 1433590 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lack of association between prior depressive episodes and cerebral [11C]PiB binding
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-β (Aβ) levels using [11C] Pittsburgh Compound B (PiB) positron emission tomography (PET) in a group of nondemented patients with prior depressive episodes. Twenty-eight elderly patients (mean age 61 years, range 51-75, 18 women) with onset of first depressive episode more than 6 years ago but now remitted from depression and 18 healthy subjects (mean age 61 years, range 50-76, 12 women) were included. All subjects were investigated with cognitive testing, 3T magnetic resonance imaging (MRI) and [11C]PiB high resolution research tomography (HRRT) positron emission tomography scan. There was no between-groups difference in [11C]PiB binding (p = 0.5) and no associations to number of depressive episodes, cognitive performance, or antidepressant treatment. Patients with late onset of depression had increased severity of white matter lesions (p = 0.04). In this study depressive episodes were not associated with increased levels of [11C]PiB. Thus, our results do not support the notion that depressive episodes previously in life are a risk factor for developing AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 10, October 2012, Pages 2334-2342
Journal: Neurobiology of Aging - Volume 33, Issue 10, October 2012, Pages 2334-2342
نویسندگان
Karine Madsen, Bo J. Hasselbalch, Kristian S. Frederiksen, Mette E. Haahr, Anders Gade, Ian Law, Julie C. Price, Gitte M. Knudsen, Lars V. Kessing, Steen G. Hasselbalch,