کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6809523 | 1433596 | 2012 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus
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کلمات کلیدی
IL-1βBDNF mRNAinflammation - التهاب( توروم) Exons - اکسونinterleukin-1 - اینترلوکین-1LTP - تقویت طولانی مدت یا LTP Memory - حافظهDendrites - دندریت هاAging - سالخوردگیCytokines - سیتوکین هاInfection - عفونتlipopolysaccharide - لیپوپلی ساکاریدTranscripts - متنHippocampus - هیپوکامپ Learning - یادگیری
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of E. coli leads to specific deficits in long-term memory and long-lasting synaptic plasticity in hippocampal area CA1-processes strongly dependent on brain-derived neurotrophic factor (BDNF). Here we have investigated the effects of age and infection on basal and fear-conditioning-stimulated expression of Bdnf in hippocampus. We performed in situ hybridization with 6 probes recognizing: total (pan-)BDNF mRNA, the 4 predominant 5â² exon-specific transcripts (I, II, IV, and VI), and BDNF mRNAs with a long 3â² untranslated region (3â² UTR). In CA1, aging reduced basal levels and fear-conditioning-induced expression of total BDNF mRNA, exon IV-specific transcripts, and transcripts with long 3â² UTRs; effects of infection were similar and sometimes compounded the effects of aging. In CA3, aging reduced all of the transcripts to some degree; infection had no effect. Effects in dentate were minimal. Northern blot analysis confirmed an aging-associated loss of total BDNF mRNA in areas CA1 and CA3, and revealed a parallel, preferential loss of BDNF mRNA transcripts with long 3â² UTRs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 4, April 2012, Pages 832.e1-832.e14
Journal: Neurobiology of Aging - Volume 33, Issue 4, April 2012, Pages 832.e1-832.e14
نویسندگان
Timothy R. Chapman, Ruth M. Barrientos, Jared T. Ahrendsen, Jennifer M. Hoover, Steven F. Maier, Susan L. Patterson,