کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6811950 1433786 2018 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Total and differential white blood cell counts and hemodynamic parameters in first-episode psychosis
ترجمه فارسی عنوان
تعداد کل گلبولهای سفید خون و دیابت و پارامترهای همودینامیک در روانپزشکی در اولین مرحله
کلمات کلیدی
روان درمانی اول نسبت نوروفیل لنفوسیت، نسبت مونوسیت-لنفوسیت، التهاب فشار نبض، مقدار فشار محصول، متوسط ​​فشار شریانی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
There is evidence for blood inflammatory abnormalities in patients with first-episode psychosis (FEP). The monocyte- and neutrophil-to-lymphocyte ratios (MLR; NLR) are markers of inflammation and endothelial dysfunction, and predictors of cardiovascular disease, the leading cause of death in schizophrenia. We investigated relationships between white blood cell (WBC) counts and hemodynamic parameters associated with cardiovascular disease risk in 25 subjects age 18-50 hospitalized for FEP and 44 controls. Subjects had a blood draw, vital signs, and medical history. Patients with FEP had significantly higher NLR, MLR, pulse pressure, and rate pressure product (RPP) than controls (p < 0.05 for each), after controlling for potential confounders. In linear regression analyses, higher monocytes were a significant predictor of higher pulse pressure (p = 0.033) and higher MLR predicted RPP at the trend level (p = 0.051) in FEP, after controlling for potential confounders. To our knowledge, ours is the first report of increased RPP, a measure of myocardial workload, in FEP. We also replicated findings of increased NLR, MLR and pulse pressure in FEP. Our findings underscore that measurement of routine vital signs and blood total and differential WBC counts are germane to the clinical care of patients with psychosis as markers of cardiovascular disease risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 260, February 2018, Pages 307-312
نویسندگان
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