کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6813623 | 545648 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders
ترجمه فارسی عنوان
ارتباط بین کراتین کیناز سرم، خلق و روان در بیماران مبتلا به اسکیزوفرنی، اختلالات دوقطبی و اسکیزوفرنست
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کلمات کلیدی
کراتین کیناز، تاثیر می گذارد، اختلالات خلقی، اختلالات روان پریشی، اختلال دو قطبی، افسردگی، روانپزشکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Previous studies demonstrated levels of serum CK (sCK) in the majority of patients undergoing acute psychosis. Records of 1054 patients hospitalized in Geha Mental Health Center during the study period were analyzed. Of them, 743 have been diagnosed with schizophrenia (Sz), 170 with schizoaffective disorder (SzA), and 158 with bipolar disorder (BP-I). Baseline sCK and PANSS values were obtained from each patient upon admission. Our results show that LnsCK is higher in patients with BP-I in comparison with patients with SZ, but not significantly different compared to patients with SzA. A multivariate analysis using linear regression model in which LnsCK was predicted by factors such as PANSS-total and sub-scores, IM injection, BMI, gender, and age among patients at each admission, revealed that PANSS-depression was inversely associated with LnsCK level in SzA and BP-I and not in SZ. A positive association was found between PANSS-total and sCK in SzA and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. After controlling for confounders, it seems that sCK level is associated with the both affective and psychotic components. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 238, 30 April 2016, Pages 333-337
Journal: Psychiatry Research - Volume 238, 30 April 2016, Pages 333-337
نویسندگان
Sarah Hollander, Eldar Hochman, Gal Shoval, Michal Taler, Sharon Trommer, Haggai Hermesh, Abraham Weizman, Amir Krivoy,