کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6815196 | 545486 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The concomitant use of second-generation antipsychotics and long-term antiretroviral therapy may be associated with increased cardiovascular risk
ترجمه فارسی عنوان
استفاده همزمان از داروهای ضد سرطان نسل دوم و درمان آنتی بادی های طولانی مدت ممکن است با افزایش خطر ابتلا به بیماری قلبی عروقی همراه باشد
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کلمات کلیدی
اچ آی وی، خطر قلبی عروقی، بیماری روانی جدی، دیابت چاقی، هیپرتریگلیسریدمی، فشار خون،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
To study the effect of concurrent use of second-generation antipsychotics (SGAs) on metabolic syndrome (MetS) components conferring increased cardiovascular risk in a sample of human immunodeficiency virus (HIV)-infected adults taking antiretroviral therapy (ART). A retrospective study of participants consecutively recruited at the UCSD HIV Neurobehavioral Research Program examined effects of combined ART and SGAs on body mass index (BMI), nonfasting serum lipids, diabetes mellitus (DM) incidence, and mean arterial pressure (MAP). Metabolic outcome variables and covariates were compared using t-tests, Chi-squared or Fisher's exact tests. Linear and logistic multivariable models explored metabolic outcomes for participants taking (SGA+) or not taking (SGAâ) concomitant SGAs, after controlling for demographic and HIV disease- and ART-related covariates. Of 2229 HIV-infected participants, 12% (N=258) were treated with SGAs. In multivariable models adjusted for relevant covariates, the SGA+ group had significantly higher mean triglycerides, significantly higher odds of DM, significantly higher MAPs and marginally higher BMI. The use of SGAs in HIV-infected adults taking ART was independently associated with worse indicators of MetS and cardiovascular risk. Aggressive monitoring for the metabolic complications from concurrent SGA and ART is indicated in all patients receiving these medication combinations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 218, Issues 1â2, 15 August 2014, Pages 201-208
Journal: Psychiatry Research - Volume 218, Issues 1â2, 15 August 2014, Pages 201-208
نویسندگان
Maria Ferrara, Anya Umlauf, Chelsea Sanders, Jonathan M. Meyer, John Allen McCutchan, Nichole Duarte, Joseph Hampton Atkinson, Igor Grant, Ronald J. Ellis, the CHARTER Group the CHARTER Group,