کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6816749 | 1433877 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amygdala volume mediates the relationship between externalizing symptoms and daily smoking in adolescence: A prospective study
ترجمه فارسی عنوان
حجم آمیگدال ارتباط بین نشانه های خارجی و سیگار کشیدن روزانه را در میان نوجوانان متمرکز می کند: یک مطالعه آینده نگر
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کلمات کلیدی
عوامل خطر، سوء مصرف مواد، حجم مغز، قشر اوربیتوفرنتال،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The current study examined amygdala and orbitofrontal cortex (OFC) volumes as mediators of the relationship between externalizing symptoms and daily smoking in adolescence. Externalizing behaviors are among the most robust predictors of adolescent smoking, and there is emerging evidence that volume reductions in the amygdala and OFC are associated with risk for substance misuse as well as aggressive, impulsive, and disinhibited tendencies. Using a prospective longitudinal design, we recruited 109 adolescents who provided data on brain volume and externalizing behaviors at age 12, and on smoking at age 18. Daily smoking at age 18 (nâ¯=â¯27) was predicted by externalizing behaviors (measured by the self-report Child Behavior Checklist, CBCL) as well as smaller right amygdala volumes. Right amygdala volumes mediated the relationship between externalizing symptoms and later smoking. These findings provide important insight into the neurobiological risk factors associated with adolescent smoking, and, more generally, into factors that may be associated with vulnerability to substance use disorders and related psychopathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 276, 30 June 2018, Pages 46-52
Journal: Psychiatry Research: Neuroimaging - Volume 276, 30 June 2018, Pages 46-52
نویسندگان
Ali Cheetham, Nicholas B. Allen, Sarah Whittle, Julian Simmons, Murat Yücel, Dan I. Lubman,