کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817162 | 862794 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
White matter structure in the uncinate fasciculus: Implications for socio-affective deficits in Autism Spectrum Disorder
ترجمه فارسی عنوان
ساختار ماده سفید در فسیکولوس بی سابقه: پیامدهای کمبود اجتماعی-عاطفی در اختلال اسپکتروم اوتیسم
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کلمات کلیدی
اختلال اسپکتروم اوتیسم، کسری اجتماعی، مقررات احساسی، فلفل دلمه ای، تصویربرداری تانسور نفوذ،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Individuals with Autism Spectrum Disorder (ASD) have social and communication deficits and difficulties regulating emotions. The brain bases of these socio-affective deficits are not yet clear, but one candidate is structural connectivity in the left uncinate fasciculus, which connects limbic temporal and frontal areas thought to be involved in socio-affective processing. In this study, we assessed white matter structure in the left and right uncinate fasciculus in 18 high-functioning individuals with ASD and 18 group-matched typically developing (TD) controls using Diffusion Tensor Imaging. To test specificity of the associations, we also examined the association between both uncinate fasciculi and restricted and repetitive behaviors. Compared to TD individuals, individuals with ASD had significantly lower fractional anisotropy (FA) in the left and right uncinate. Group status significantly moderated the association between left uncinate and socio-affective deficits, indicating that within the ASD group, FA was associated with socio-affective deficits: Individuals with ASD with lower FA in the left uncinate had significantly more social and emotion regulation deficits. There was no association with restricted and repetitive behaviors. This study provides evidence that the left uncinate may play a critical role in socio-affective skills in individuals with ASD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 255, 30 September 2016, Pages 66-74
Journal: Psychiatry Research: Neuroimaging - Volume 255, 30 September 2016, Pages 66-74
نویسندگان
Andrea C. Samson, Robert F. Dougherty, Ihno A. Lee, Jennifer M. Phillips, James J. Gross, Antonio Y. Hardan,