کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6818543 547001 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner
ترجمه فارسی عنوان
برنامه های استرس پس از زایمان پاسخ های استرس نروندوکریین و رفتارهای عاطفی در موش های نسل دوم به شیوه ای وابسته به جنس
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
F2 PNS males exhibited heightened anxiety-like behavior (light-dark box and elevated plus maze) compared with F2 control males. Anxiety-like behavior did not differ between F2 control and PNS females during metestrus/diestrus, however at proestrus/estrus, F2 control females displayed a reduction in anxiety-like behavior, but this effect was not observed in the F2 PNS females. Heightened anxiety in the F2 PNS males was associated with greater Crh mRNA expression in the central nucleus of the amygdala compared with controls. Moreover, Crh receptor-1 (Crhr1) mRNA expression was significantly increased, whereas Crhr2 mRNA was significantly decreased in discrete regions of the amygdala in F2 PNS males compared with controls, with no differences in the F2 females. No differences in depressive-like behavior (sucrose preference or forced swim test) were observed in either sex. In conclusion, the effects of maternal stress during pregnancy on HPA axis regulation and anxiety-like behavior can be transmitted to future generations in a sex-dependent manner. These data have implications for human neuropsychiatric disorders with developmental origins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 62, December 2015, Pages 204-216
نویسندگان
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