کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6819398 547103 2015 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of cortisol on cognition in major depressive disorder, posttraumatic stress disorder and borderline personality disorder - 2014 Curt Richter Award Winner
ترجمه فارسی عنوان
اثرات کورتیزول بر شناخت در اختلال افسردگی، اختلال استرس پس از سانحه و اختلال شخصیت مرزی - 2014 برنده جوایز کورت ریشتر
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
In a series of studies, we investigated the effects of glucocorticoids on cognition (i.e. declarative memory, working memory and response inhibition) in different mental disorders such as MDD, PTSD and BPD. While in patients with MDD cortisol administration failed to effect memory retrieval, patients with PTSD and BPD showed enhanced rather than impaired memory retrieval after cortisol administration. These results indicate an altered sensitivity to cortisol in these disorders. Results from one of our recent studies in the field of social cognition underline the importance of the MR. We found that emotional empathy was enhanced through stimulation of the MR via fludrocortisone in healthy participants and women with BPD. This review aims to integrate these findings and discuss potential mechanisms and implications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 51, January 2015, Pages 282-295
نویسندگان
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