An efficient protocol for regioselective ring opening of epoxides using samarium triflate: Synthesis of propranolol, atenolol and RO363

The oxiranes undergo rapid ring opening reaction with amines catalyzed by samarium triflate under mild reaction conditions. The reactions were carried out at below room temperature to afford the corresponding β-amino alcohols in excellent yields and high regioselectivity. This protocol has been applied for the synthesis of various β-blockers.

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