کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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68302 | 48511 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chiral ketone- or chiral amine-catalyzed asymmetric epoxidation of cis-1-propenylphosphonic acid using hydrogen peroxide as oxidant Chiral ketone- or chiral amine-catalyzed asymmetric epoxidation of cis-1-propenylphosphonic acid using hydrogen peroxide as oxidant](/preview/png/68302.png)
By using a d-fructose-derived chiral ketone or a d-mannitol-derived chiral amine as catalyst, the organocatalytic asymmetric epoxidation of cis-1-propenylphosphoric acid with 30% aqueous hydrogen peroxide in H2O–CH3CN mixture (∼80:20) afforded (1R, 2S)-(−)-(1,2)-epoxypropyl phosphoric acid (fosfomycin). Asymmetric epoxidation was carried out at 0 °C for 72 h to achieve 100% conversion with a maximum enantiomeric excess (e.e.) of 74%.
By using a d-fructose-derived chiral ketone or a d-mannitol-derived chiral amine as catalyst and 30% aqueous hydrogen peroxide as oxidant, the organocatalytic asymmetric epoxidation of cis-1-propenylphosphoric acid afforded (1R, 2S)-(−)-(1,2)-epoxypropyl phosphoric acid. At 0 °C for 72 h, the enantiomeric excess (e.e.) reached 74% at 100% conversion.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 285, Issues 1–2, 18 April 2008, Pages 68–71