Synthesis of 8-aryl-1H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-a] pyrimidine-4(5H)-imine by using the Preyssler's anion [NaP5W30O110]14− as a green and eco-friendly catalyst

Reaction of 6-hydrazino-1,5-diphenyl-1H-pyrazolo[3,4-d]pyrimidine-4-imine with aromatic aldehyde in presence of Preyssler catalyst yielded 8-aryl-1H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-a] pyrimidine-4(5H)-imine. The performance of different form of Preyssler's anions including H14[NaP5W30O110], H14-P5, mixed-addenda H14[NaP5W29 MoO110], H14-P5Mo, silica supported H14[NaP5W30O110]/SiO2 and H14-P5/SiO2 have been investigated. The reaction results were compared with that of a conventional acid catalyst (H2SO4).

Preyssler's polyanion H14[NaP5W30O110] (H14-P5) have proved to be an efficient heterogeneous catalysts for reaction of 6-hydrazino-1,5-diphennyl-1H-pyrazolo[3,4-d]pyrimidine -4-imine with aromatic aldehyde to yield 8-aryl-1H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidine-4(5H)-imine. Figure optionsDownload as PowerPoint slide