A new route for isoquinolines catalyzed by palladium

3-Bromopyridine-4-carbaldehyde is tethered with suitably electron withdrawing group substituted alkenes via Heck coupling followed by aldol reaction in dioxane at 150 °C under a catalytic system of Pd(OAc)2/PPh3/NaOAc to afford the corresponding isoquinolines in good yields.

3-Bromopyridine-4-carbaldehyde is cyclized with suitably electron withdrawing group substituted alkenes in the presence of a palladium catalyst to give isoquinolines. Figure optionsDownload as PowerPoint slide