کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
683707 889005 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تکنولوژی و شیمی فرآیندی
پیش نمایش صفحه اول مقاله
Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology
چکیده انگلیسی

Response surface methodology was employed to optimize the composition of medium for the production of avermectin B1a by Streptomyces avermitilis 14-12A in shaker flask cultivation. Corn starch and yeast extract were found to have significant effects on avermectin B1a production by the Plackett–Burman design. The steepest ascent method was used to access the optimal region of the medium composition, followed by an application of response surface. The analysis revealed that the optimum values of the tested variables were 149.57 g/l corn starch and 8.92 g/l yeast extract. A production of 5128 mg/l, which was in agreement with the prediction, was observed in verification experiment. In comparison to the production of original level (3528 mg/l), 1.45-fold increase had been obtained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioresource Technology - Volume 100, Issue 17, September 2009, Pages 4012–4016
نویسندگان
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