Efficient Suzuki cross-coupling reactions using bulky phosphines

A series of phosphines, P(biphenyl)nPh3−n has been used as co-catalyst in the palladium catalyzed Suzuki cross-coupling reaction of aryl-bromides and -chlorides. The effects of the phosphine, palladium source, base, solvent and promoter salt were investigated. High conversions and turnovers were obtained in all studied phosphines, particularly using P(biphenyl)Ph2 which can be interpreted by the contribution of steric and electronic effects.

A series of phosphines, P(biphenyl)nPh3−n has been used as co-catalyst in the palladium catalyzed Suzuki cross-coupling reaction of aryl-bromides and -chlorides. High conversions and turnovers were obtained in all studied phosphines. Figure optionsDownload as PowerPoint slide