کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
68500 | 48515 | 2006 | 9 صفحه PDF | دانلود رایگان |
The present article summarises imidoosmium-catalysed oxidations of alkenes to yield 2-amino ketones. Three different approaches are discussed. The first section describes the direct conversion of alkenes to yield racemic 2-amino ketone products in what represents a so-far unknown reactivity in osmium catalysis. It is followed by the description of a two-step procedure, which converts alkenes into enantiomerically pure vicinal amino alcohols followed by stereoselective oxidative conversion into 2-amino ketones. Both pathways derive from a common mechanistic background and constitute a novel side-reaction of the original aminohydroxylation chemistry. An alternative synthetic approach of osmium-catalysed aminohydroxylation of silyl enol ethers is discussed as well and is compared to the previous two procedures.
The first examples of direct conversion of alkenes to yield racemic 2-amino ketone products in what represents a so-far unknown reactivity in osmium catalysis are presented. In addition, a two-step procedure, which converts alkenes into enantiomerically pure vicinal amino alcohols followed by stereoselective oxidative conversion into 2-amino ketones is described. Both pathways derive from a common mechanistic background and constitute a novel side-reaction of the original aminohydroxylation chemistry. Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 251, Issues 1–2, 17 May 2006, Pages 277–285