کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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68749 | 48522 | 2006 | 4 صفحه PDF | دانلود رایگان |
ROM–RCM (ring-opening metathesis and ring-closing metathesis) of azabicyclo[2.2.1]heptene-ynes using the second-generation Grubbs catalyst was investigated. When an azabicycloheptene derivative was exposed to a catalytic amount of a ruthenium carbene complex, pyrrolizidine and indolizidine derivatives were obtained in good yields. The distribution of these products depends on the substituents on the alkyne.
When an azabicycloheptene derivative 1a was exposed to a catalytic amount of a ruthenium carbene complex 3, indolizidine derivative 2a was obtained as a main product along with a fair amount of pyrrolizidine derivative 4a. However, pyrrolizidine derivative 2c was obtained as a major product, when the reaction of 1c was carried out under the same reaction conditions. Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 254, Issues 1–2, 19 July 2006, Pages 64–67