Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics

Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis (RCAM) in biologically relevant biomolecules in order to introduce alkene- and/or alkyne-bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability.

Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis in biologically relevant biomolecules in order to introduce alkene- and/or alkyne bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability.Figure optionsDownload as PowerPoint slide