Exploiting catalyst characteristics: A protocol for increasing diastereoselectivity in a double ring-closing metathesis reaction

A procedure for obtaining increased selectivity in a diastereoselective double ring-closing metathesis reaction is presented. The key to success was design of a substrate, which directed the reaction mechanism through a selective pathway and use of a suitable catalyst combination to achieve the desired balance between reactivity and selectivity.

A procedure for obtaining increased selectivity in a diastereoselective double ring-closing metathesis reaction is presented. The key to success was design of a substrate, which directed the reaction mechanism through a selective pathway and use of a suitable catalyst combination to achieve the desired balance between reactivity and selectivity. Figure optionsDownload as PowerPoint slide