کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
68835 48524 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insight into Friedel-Crafts acylation of 1,4-dimethoxybenzene to 2,5-dimethoxyacetophenone catalysed by solid acids—mechanism, kinetics and remedies for deactivation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Insight into Friedel-Crafts acylation of 1,4-dimethoxybenzene to 2,5-dimethoxyacetophenone catalysed by solid acids—mechanism, kinetics and remedies for deactivation
چکیده انگلیسی

Friedel-Crafts acylation of aromatic ethers is challenging, which frequently encounters rapid catalyst deactivation by the ether. Although H-Y and H-β are known to perform better, there is still deactivation due to both the ether and the acylated ether. In the current work, the synthesis of 2,5-dimethoxyacetophenone, an intermediate used in the production of fine chemicals, was carried out via acylation of 1,4-dimethoxybenzene with acetic anhydride over various solid acid catalysts such as sulfated zirconia, UDCaT-1, UDCaT-5, 20% w/w H3P12W40/K10, 20% w/w Cs2.5H0.5P12W40/K10, Amberlyst-15 and Indion-125. The cation exchange resins, Amberlyst-15 and Indion-125, were superior to other inorganic solid acids. A systematic study was undertaken to understand the reaction mechanism and catalyst functioning with Indion-125. The catalyst gets deactivated slowly over repeated use and this was studied independently. The adsorption of reactants and products was studied from pure component solutions and mixtures. The experimental data so generated were used to develop a model, incorporating deactivation. The model fits the experimental data very well. The current work gives an insight into choice of catalyst, kinetic modeling, studies in catalyst deactivation and methods to avoid deactivation.

Acylation of 1,4 dimethoxybenzene with acetic anhydride is studied systematically over several solid acids and the ion exchange resins were found to be superior.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis A: Chemical - Volume 264, Issues 1–2, 1 March 2007, Pages 179–191
نویسندگان
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