Lanthanum(III) nitrate hexahydrate or gadolinium(III) chloride hexahydrate catalyzed one-pot synthesis of α-amino nitriles

A simple, convenient and general method has been developed for the synthesis of α-aminonitriles by a one-pot three component condensation of aldehydes, amines and trimethyl silyl cyanide in acetonitrile in the presence of a catalytic amount of La(NO3)3·6H2O or GdCl3·6H2O.

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