کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6892314 | 1445353 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A mathematical model of tumor hypoxia targeting in cancer treatment and its numerical simulation
ترجمه فارسی عنوان
یک مدل ریاضی هیپوکسیا تومور در درمان سرطان و شبیه سازی عددی آن است
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
چکیده انگلیسی
Solid tumor includes the areas where oxygen concentration is very low called hypoxia, often in the surrounding areas of necrosis. Hypoxic cells in these areas are resistant to chemotherapy and radiation therapy. The presence of hypoxia and necrosis enables tumor-selective treatment, including hypoxia-activated prodrugs, tumor hypoxia-specific gene therapy and tumor-targeting bacterial therapy. This article deals with the mathematical formulation of tumor hypoxia-targeting by introducing a decay parameter of oxygen in the model given by Kolobov et al. (2009) and Avila et al. (2013). The well-posedness of the governing partial differential equations and numerical simulation are provided. For the purpose of numerical simulations, the conforming Q1 finite element method for space discretization and second-order diagonally implicit fractional step θ-scheme for temporal discretization are used. The effect of oxygen on hypoxia, necrotic region decay and the maximum age of growing tumor cells are computed and illustrated graphically. It is observed that the distribution of nutrients in tissues have substantial effect on tumor growth rate and structure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Mathematics with Applications - Volume 74, Issue 12, 15 December 2017, Pages 3250-3259
Journal: Computers & Mathematics with Applications - Volume 74, Issue 12, 15 December 2017, Pages 3250-3259
نویسندگان
Muhammad Sabir, Abdullah Shah, Wazir Muhammad, Ijaz Ali, Peter Bastian,