A productivity signal feedback controller for continuous bioreactors

The control of continuous stirred bioreactors using productivity signal feedback consists of using the direct relation between the optimal static dilution rate and the optimal static productivity. This strategy drives the bioprocess to its optimal productivity point, irrespective of the feeding substrate concentration, and specific growth rate or substrate concentration estimates. While the algorithm covers a wide class of bioprocesses, explicit relations are given for the Monod and Haldane cases.

► We model optimal productivity in a fermenter with substrate dependent growth rate.
► Optimal productivity and dilution rate are related, independent of feed concentration.
► A controller using the optimal curve reaches the optimal point.
► This controller only requires productivity feedback.
► The Monod and Haldane cases are given and compared to the chemostat.