N-oxidation of pyridine carboxylic acids using hydrogen peroxide catalyzed by a green heteropolyacid catalyst: Preyssler's anion, [NaP5W30O110]14−

The catalytic oxidation of pyridine carboxylic acids such as nicotinic acid, picolinic acid and quniolinic acid to the corresponding N-oxides has been studied using hydrogen peroxide as an oxidant and Preyssler's catalyst as pure acid, H14[NaP5W30O110] and mixed addenda, H14[NaP5W29MoO110]. The highly selective oxidations, gave good yields of the related N-oxides along with decarboxylation of the amines. In the production of pyridine N-oxides, the position of COOH group is found to play an important role in the product type and decarboxylation is only taken place at 2-position of nitrogen. The oxidation reactions were extended to other tertiary amines.

Preyssler heteropolyacid with exclusive properties and along with retention of structure, in the presence of hydrogen peroxide catalyzes N-oxidation of the pyridine carboxylic acids to the related N-oxides with decarboxylation in 2-position with respect to nitrogen.Figure optionsDownload high-quality image (24 K)Download as PowerPoint slide