Phosphite and thiourea ligand synergy for rhodium catalyzed enantioselective hydroformylation of styrene

New non-C2-symmetric chiral diphosphites have been synthesized and used as ligands in the rhodium catalyzed enantioselective and regioselective hydroformylation of styrene. A synergistic effect improving both activity and enantioselectivity is observed when a chiral dithiourea is introduced as co-ligand in the Rh-diphosphite catalytic system.

New non-C2-symmetric chiral diphosphites have been synthesized and used as ligands in the rhodium catalyzed enantioselective and regioselective hydroformylation of styrene. A synergistic effect improving both activity and enantioselectivity is observed when a chiral dithiourea is introduced as co-ligand in the Rh-diphosphite catalytic system .Figure optionsDownload as PowerPoint slide