Dendritic BIPHEP: Synthesis and application in asymmetric hydrogenation of β-ketoesters

A series of new chiral dendritic BIPHEP ligands have been prepared and their applications in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters were investigated. Ruthenium catalysts containing these dendrimer ligands were effective in the hydrogenation of β-ketoesters. It was found that the size of the dendritic wedges influenced the enantioselectivity significantly.

New kind of chiral dendritic BIPHEP ligands have been prepared and their applications in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters were investigated. Ruthenium catalysts containing these dendrimer ligands were effective in the hydrogenation of β-ketoesters. It was found that the size of the dendritic wedges influenced the enantioselectivity significantly.Figure optionsDownload as PowerPoint slide