کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
691084 | 1460434 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Micro concentrations of Ru(III) used as homogenous catalyst in the oxidation of levothyroxine by N-bromosuccinimide and the mechanistic pathway
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تکنولوژی و شیمی فرآیندی
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چکیده انگلیسی
In this paper, we report the micro concentration of Ru(III) used as homogenous catalysis in the oxidation of levothyroxine by N-bromosuccinimide and the results of a spectrophotometric investigation of the mechanistic pathway. Such studies are helpful in gaining an insight into the interaction of metal ions through the investigation of the mechanistic pathway of levothyroxine in redox reaction.The reaction stoichiometry is 1:1 in the presence of catalyst. The oxidation products of levothyroxine have been identified as 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetaldehyde and succinimide by TLC, UV and FTIR. The reaction rate was examined with reference to variations in ionic strength, solvent polarity, free radicals, halides ions, mercuric acetate for the sequestration of Brâ in the reaction mixture and the addition of the product succinimide (RNH). The reaction constants involved in the mechanism were computed. The overall activation parameters have been evaluated from the Arrhenius plot. The observed results have been explored by proposed mechanisms, and the relative rate laws have been evaluated further.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Taiwan Institute of Chemical Engineers - Volume 45, Issue 1, January 2014, Pages 127-133
Journal: Journal of the Taiwan Institute of Chemical Engineers - Volume 45, Issue 1, January 2014, Pages 127-133
نویسندگان
Aftab Aslam Parwaz Khan, Anish Khan, Abdullah M. Asiri, Naved Azum, Malik Abdul Rub,