Asymmetric pinacol coupling reaction catalyzed by dipeptide-type Schiff bases

Several dipeptide Schiff bases and its mimics were conveniently synthesized from natural amino acids. Their titanium complexes were investigated in pinacol coupling reaction for the first time; good yields, high diastereoselectivity and moderate enantioselectivity were obtained.

Several dipeptide Schiff bases and its mimics were synthesized conveniently from natural amino acids. Their titanium complexes were investigated in pinacol coupling reaction for the first time; good yields, high diastereoselectivity and moderate enantioselectivity were obtained. Figure optionsDownload as PowerPoint slide