کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
696269 | 890330 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: ‘Closing the loop’ in biological systems modeling — From the in silico to the in vitro ‘Closing the loop’ in biological systems modeling — From the in silico to the in vitro](/preview/png/696269.png)
This work presents a holistic ‘closed loop’ approach for the development of models of biological systems. The ever-increasing availability of experimental information necessitates the advancement of a systematic methodology to organise and utilise these data. Herein, we present a biological model building framework that maps the treatment of the information from the initial conception of the model, through its experimental validation and finally to its application in model-based optimisation studies. We highlight and discuss current issues associated with the development of mathematical models of biological systems and share our perspective towards a holistic ‘closed loop’ approach that will facilitate the control of the in vitro through the in silico.
Journal: Automatica - Volume 47, Issue 6, June 2011, Pages 1147–1155