کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
696280 890330 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synchronization and activation in a model of a network of ββ-cells
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی کنترل و سیستم های مهندسی
پیش نمایش صفحه اول مقاله
Synchronization and activation in a model of a network of ββ-cells
چکیده انگلیسی

Islets of pancreatic ββ-cells are of utmost importance in the understanding of diabetes mellitus. We consider here a model of a network of such pancreatic ββ-cells which are globally coupled via gap junctions. Some of the cells in the islet produce bursting oscillations while other cells are inactive. We prove that the cells in the islet synchronize if the coupling is sufficiently large and all cells are active (or inactive). If the islet consists of both active and inactive cells and the coupling is sufficiently large, an active cluster and an inactive cluster emerge. We show that activity of the islet depends on the coupling strength and the number of active cells compared to the number of inactive cells. If too few cells are active the islet becomes inactive.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Automatica - Volume 47, Issue 6, June 2011, Pages 1243–1248
نویسندگان
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