کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6972673 | 1453142 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of coal tar pitch and smoke extract components and their cytotoxicity on human bronchial epithelial cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
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چکیده انگلیسی
Coal tar pitch and its smoke are considered hazardous by-products and common pollutant generated from coal industry processing. In this study, coal tar pitch and its smoke extracts were characterized by gas chromatography/mass spectrometry (GC/MS) with dimethylsulfoxide. We identified only 0.3025% of components in the total coal tar pitch using GC/MS. Among 18 identified compounds, polycyclic aromatic hydrocarbons (PAHs) has the highest relative abundance (0.19%). The remaining components were composed of monocyclic aromatic hydrocarbons, heterocyclic compounds and alkenes. In contrast, among 38 coal tar pitch smoke extract constituents that have been profiled, 87.91% were PAHs, and the remaining 12.09% were composed of monocyclic aromatic hydrocarbons, heterocyclic compounds and alkenes. The cytotoxic effect of coal tar pitch and its smoke extracts on BEAS-2B cells were also evaluated by MTT assay. BEAS-2B cells exposed to coal tar pitch showed a non dose-dependent U-shaped cytotoxicity with a dosage for maximal inhibitory of 3.75Â mg/L. In contrast, BEAS-2B cells exposed to coal tar pitch smoke extracts showed a dose dependent cytotoxicity with a LC50 of 8.64Â mg/L. Our study demonstrated the significant different composition and cytotoxicity of coal tar pitch and its extracts, suggesting two different underlying mechanisms that are pending future investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 186, Issues 2â3, 28 February 2011, Pages 1277-1282
Journal: Journal of Hazardous Materials - Volume 186, Issues 2â3, 28 February 2011, Pages 1277-1282
نویسندگان
Zhitao Li, Yongjun Wu, Yong Zhao, Lixia Wang, Hansong Zhu, Lijuan Qin, Feifei Feng, Wei Wang, Yiming Wu,