Development of novel mesoporous nanomatrix-supported lipid bilayers for oral sustained delivery of the water-insoluble drug, lovastatin

- A novel lipid enveloped mesoporous nanomatrix (MN-SLB) was developed.
- The potential of MN-SLB as an oral drug carrier was evaluated for the first time.
- MN-SLB showed a sustained release pattern with no dramatic initial burst effect.
- The mechanism of improvement in the solubility and oral absorption of lovastatin was investigated.