Cationic liposomes evoke proinflammatory mediator release and neutrophil extracellular traps (NETs) toward human neutrophils

- We examined the effect of cationic liposomes on human neutrophil activation.
- The cytotoxicity of liposomes was mainly associated with membrane damage.
- The toxicity of cationic liposomes should be considered when applying into bodies.
- This is the first study providing the evidence of NET production by nanoparticles.