Fabrication of a novel scaffold of clotrimazole-microemulsion-containing nanofibers using an electrospinning process for oral candidiasis applications

- Nanofiber mats containing clotrimazole (CZ)-loaded microemulsion were developed as an alternative for oral candidiasis applications.
- Microemulsion particles were observed to be regularly distributed within the mats.
- The DSC and PXRD results revealed the amorphous state of the CZ-loaded microemulsions incorporated in the nanofiber mats.
- The nanofiber mats exhibited more rapid killing activity than commercial CZ lozenges did.