Oligomers, protofibrils and amyloid fibrils from recombinant human lysozyme (rHL): Fibrillation process and cytotoxicity evaluation for ARPE-19 cell line

- Hydrophobicity, size and shape of rHL aggregates promote the formation of amyloid fibrils.
- The adsorption of pre-amyloid fibrils at the air-water interface has correlation with the secondary structure.
- The cytotoxicity of amyloid fibrils has relation with the gain of the cross-β-sheet conformation.
- Pre-amyloid of rHL isolated after 600 min incubation resulted more toxic for the ARPE-19 cells.