Tailored polymer-lipid hybrid nanoparticles for the delivery of drug conjugate: Dual strategy for brain targeting

- Glioblastoma treatment remains a challenge owing to the impermeability of BBB.
- Targeting of the drug to the glioma cells after transportation across BBB is a critical factor.
- PLNs are merged with the benefits of both polymeric nanoparticles and liposomes.
- The folic acid targeted polymer-lipid hybrid nanoparticles (PLNs) enhance BBB penetration.
- Encapsulated drug peptide conjugate was developed to subsequently target to the glioma cells.