Construction of pH-sensitive lysozyme/pectin nanogel for tumor methotrexate delivery

- A versatile nanogels was synthesized through self-assembly.
- MTX was effectively loaded into the nanogels with a high loading content.
- The MTX release from MTX-loaded nanogels was accelerated in acid conditions.
- MTX-loaded nanogels exhibited enhanced cytotoxicity and greater apoptotic effects.