Enhanced antimelanoma activity of methotrexate and zoledronic acid within polymeric sandwiches

- Methotrexate and zoledronic acid loaded into tecto-dendrimers (MTX- and ZOL-sandwiches) are proposed to enhanced activity of the drugs on melanoma cells.
- MTX- and ZOL-sandwiches showed higher cytotoxicity to melanoma cells than free drugs and tecto-dendrimers alone.
- MTX-sandwiches was cytotoxic to melanoma cells and harmless to keratinocytes.
- MTX-sandwiches was uptaken by macropinocytosis avoiding methotrexate exocytosis.