PEGylated galactosylated cationic liposomes for hepatocytic gene delivery

- “Stealth” and glycotargeted cationic liposomes for ASGP-R targeting.
- PEGylation greatly reduced liposome and lipoplex size.
- Higher PEGylated lipoplexes show superior transfection efficiency in vitro.
- Density of PEG and lipoplex N/P (+:−) ratio strongly affect transfection levels.
- Specific ASGP-R mediated gene transfection was confirmed.