کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6982979 | 1454284 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration
ترجمه فارسی عنوان
تجزیه پذیری، انعطاف پذیری و بازخورد درون سلولی به سیلیکات منیزیم مزوپور برای القای بازسازی استخوان
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کلمات کلیدی
سیلیسیم منیزیم بینزوپور، جذب آب، تنزل، مواد بیولوژیکی، سیتو سازگاری،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
چکیده انگلیسی
Mesoporous magnesium silicate (m-MS) was synthesized, and the in vitro degradability, bioactivity and primary cell responses to m-MS were investigated. The results suggested that the m-MS with mesoporous channels of approximately 5Â nm possessed the high specific surface area of 451.0Â m2/g and a large specific pore volume of 0.41Â cm3/g compared with magnesium silicate (MS) without mesopores of 75Â m2/g and 0.21Â cm3/g, respectively. The m-MS was able to absorb a large number of water, with water absorption of 74% compared with 26% for MS. The m-MS was also degradable in a Tris-HCl solution, with a weight loss ratio of 40Â wt% after a 70-day immersion period. The m-MS exhibited good in vitro bioactivity, inducing apatite formation on its surfaces after soaking in simulated body fluid (SBF) at a faster rate than observed for MS. The m-MS surface clearly promoted the proliferation and differentiation of MC3T3-E1 cells, and their normal cell morphology indicated excellent cytocompatibility. This study suggested that mesoporous magnesium silicate with a high specific surface area and pore volume had suitable degradability and good bioactivity and biocompatibility, making it an excellent candidate biomaterial for the induction of bone regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 120, 1 August 2014, Pages 38-46
Journal: Colloids and Surfaces B: Biointerfaces - Volume 120, 1 August 2014, Pages 38-46
نویسندگان
Zhaoying Wu, Tingting Tang, Han Guo, Songchao Tang, Yunfei Niu, Jue Zhang, Wenjing Zhang, Rui Ma, Jiacan Su, Changsheng Liu, Jie Wei,