Comparison of polymer induced and solvent induced trypsin denaturation: The role of hydrophobicity

- Epoxy activated copolymer reacted with different amines of varying hydrophobicity.
- Trypsin binds and denatures increasingly with hydrophobicity of the amine.
- Linear correlation of log Poctanol of amine with trypsin binding.
- Similarities with enzyme denaturation by organic solvents in water.