Low-dose chemotherapy of hepatocellular carcinoma through triggered-release from bilayer-decorated magnetoliposomes

- Stimuli-responsive magnetoliposomes (dMLs) were designed for low dose chemotherapy.
- SPIO nanoparticles provided a bilayer trigger for intracellular doxorubicin release.
- High dML uptake was observed in Huh-7 cell line in vitro.
- dMLs exhibited low cytotoxicity unless activated by an external RF field.
- Huh-7 treatment was due to doxorubicin release and not local hyperthermia.