Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds

- Fabricating porous hydrogel scaffolds through pH-triggered co-precipitation of the cartilage extracellular matrix (ECM) components of chondroitin sulfate (CS) and collagen (COL) to mimic in vivo ECM.
- Controllable release of transforming growth factor-β (TGF-β) and collagen binding domain-basic fibroblast growth factor (CBD-bFGF) in hydrogel network.
- Regulating human mesenchymal stem cells differentiation into chondrocytes via the controllably released growth factors.