Adsorption, structural alteration and elution of peptides at pendant PEO layers

- α-Helical peptides penetrate PEO brushes, while “disordered” conformations do not.
- Peptide α-helicity increases in the hydrophobic inner region within a PEO brush.
- The elutability of non-amphiphilic peptides depends on bulk solution conditions.
- Amphiphilic peptides are resistant to elution, regardless of solution conditions.
- Structure-based peptide-PEO associations may enable novel drug delivery strategies.