Evaluation of clay/poly (l-lactide) microcomposites as anticancer drug, 6-mercaptopurine reservoir through in vitro cytotoxicity, oxidative stress markers and in vivo pharmacokinetics

- Intercalation of 6-mercaptopurine (6-MP) in Na+-clay (MMT) by ion exchange method.
- Entrapment of 6-MP-MMT in poly (l-lactide) matrix to form microcomposite sphere.
- Reduction of cell cytotoxic and oxidative stress marker indices in IMR32 cells.
- In vivo pharmacokinetics of 6-MP-MMT and MPs with pristine 6-MP in female wistar rats.