Gold nanoparticles as amyloid-like fibrillogenesis inhibitors

- Nanoparticles can cross blood-brain-barrier and target amyloidogenic structures.
- AuNPs affect the protein structure and dynamics of insulin fibril for aggregation.
- AuNPs delayed amyloid-like fibrils formation by about 1 week.
- AuNPs disrupt fibrillogenesis resulting in fibrils are shorter and more compact.